Pratap, Amitesh, Garner, Kathryn, Voliotis, Margaritis, Tsaneva-Atanasova, Krasimira and McArdle, Craig A. (2017) Mathematical modeling of gonadotropin-releasing hormone signaling. Molecular and Cellular Endocrinology, 449. pp. 42-55. ISSN 0303-7207
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Abstract
Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GnRH, GPCR, NFAT, ERK, Mathematical modeling, Mutual information |
| Subjects: | C500 Microbiology G100 Mathematics |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | John Coen |
| Date Deposited: | 03 Jun 2020 14:18 |
| Last Modified: | 31 Jul 2021 17:35 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/43335 |
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