A new threat from an old enemy: Re‑emergence of coronavirus (Review)

Docea, Anca, Tsatsakis, Aristidis, Albulescu, Dana, Cristea, Oana, Zlatian, Ovidiu, Vinceti, Marco, Moschos, Sterghios, Tsoukalas, Dimitris, Goumenou, Marina, Drakoulis, Nikolaos, Dumanov, Josef, Tutelyan, Victor, Onischenko, Gennadii, Aschner, Michael, Spandidos, Demetrios and Calina, Daniela (2020) A new threat from an old enemy: Re‑emergence of coronavirus (Review). International Journal of Molecular Medicine, 45 (6). pp. 1631-1643. ISSN 1107-3756

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Official URL: https://doi.org/10.3892/ijmm.2020.4555


The new outbreak of coronavirus from December 2019 has brought attention to an old viral enemy and has raised concerns as to the ability of current protection measures and the healthcare system to handle such a threat. It has been known since the 1960s that coronaviruses can cause respiratory infections in humans; however, their epidemic potential was understood only during the past two decades. In the present review, we address current knowledge on coronaviruses from a short history to epidemiology, pathogenesis, clinical manifestation of the disease, as well as treatment and prevention strategies. Although a great amount of research and efforts have been made worldwide to prevent further outbreaks of coronavirus‑associated disease, the spread and lethality of the 2019 outbreak (COVID‑19) is proving to be higher than previous epidemics on account of international travel density and immune naivety of the population. Only strong, joint and coordinated efforts of worldwide healthcare systems, researchers, and pharmaceutical companies and receptive national leaders will succeed in suppressing an outbreak of this scale.

Item Type: Article
Subjects: B100 Anatomy, Physiology and Pathology
B200 Pharmacology, Toxicology and Pharmacy
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Elena Carlaw
Date Deposited: 25 Jun 2020 08:44
Last Modified: 31 Jul 2021 11:33
URI: http://nrl.northumbria.ac.uk/id/eprint/43575

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