Giacomin, Paul R., Kraeuter, Ann-Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengtsson, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán and Soares Magalhães, Ricardo J. (2018) Chronic Helminth Infection Perturbs the Gut-Brain Axis, Promotes Neuropathology, and Alters Behavior. The Journal of Infectious Diseases, 218 (9). pp. 1511-1516. ISSN 0022-1899
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Abstract
Helminth infections in children are associated with impaired cognitive development; however, the biological mechanisms for this remain unclear. Using a murine model of gastrointestinal helminth infection, we demonstrate that early-life exposure to helminths promotes local and systemic inflammatory responses and transient changes in the gastrointestinal microbiome. Behavioral and cognitive analyses performed 9-months postinfection revealed deficits in spatial recognition memory and an anxiety-like behavioral phenotype in worm-infected mice, which was associated with neuropathology and increased microglial activation within the brain. This study demonstrates a previously unrecognized mechanism through which helminth infections may influence cognitive function, via perturbations in the gut-immune-brain axis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cognition, helminth, inflammation, microbiome |
| Subjects: | B100 Anatomy, Physiology and Pathology C500 Microbiology C800 Psychology |
| Department: | Faculties > Health and Life Sciences > Psychology |
| Depositing User: | Elena Carlaw |
| Date Deposited: | 20 Aug 2020 15:05 |
| Last Modified: | 31 Jul 2021 12:19 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/44147 |
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