The Relationship between Fatigue and Actigraphy-Derived Sleep and Rest–Activity Patterns in Cancer Survivors

Martin, Tristan, Twomey, Rosie, Medysky, Mary E., Temesi, John, Culos-Reed, S. Nicole and Millet, Guillaume Y. (2021) The Relationship between Fatigue and Actigraphy-Derived Sleep and Rest–Activity Patterns in Cancer Survivors. Current Oncology, 28 (2). pp. 1170-1182. ISSN 1198-0052

[img]
Preview
Text
curroncol-28-00113.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (4MB) | Preview
[img]
Preview
Text
Martin_et_al._Author_accepted_manuscript_with_online_supplemental_material_included.pdf - Accepted Version
Available under License Creative Commons Attribution 4.0.

Download (453kB) | Preview
Official URL: https://doi.org/10.3390/curroncol28020113

Abstract

Background Cancer-related fatigue can continue long after curative cancer treatment. The aim of this study was to investigate sleep and rest-activity cycles in fatigued and non-fatigued cancer survivors. We hypothesized that sleep and rest-activity cycles would be more disturbed in people experiencing clinically-relevant fatigue, and that objective measures of sleep would be associated with the severity of fatigue in cancer survivors. Methods: Cancer survivors (n=87) completed a 14-day wrist actigraphy measurement for the estimation of sleep and rest-activity cycles. Fatigue was measured using the Functional Assessment of Chronic Illness Therapy-Fatigue Scale (FACIT-F). Participants were dichotomised into two groups using a previously validated score (fatigued n=51 and non-fatigued n=36). Perception of sleep was measured using the Insomnia Severity Index (ISI). Results: FACIT-F score was correlated with wake after sleep onset (r =-0.28; p = 0.010), sleep efficiency (r=0.26; p=0.016), sleep onset latency (r=-0.31; p=0.044) and ISI score (r=-0.56; p <0.001). The relative amplitude of the rest-activity cycles was lower in the fatigued vs. non-fatigued group (p=0.017; d=0.58). Conclusions: After treatment for cancer, the severity of cancer-related fatigue is correlated with specific objective measures of sleep, and there is evidence of rest-activity cycle disruption in people experiencing clinically-relevant fatigue.

Item Type: Article
Uncontrolled Keywords: insomnia, rest-activity cycle, actigraphy, cancer-related fatigue
Subjects: B100 Anatomy, Physiology and Pathology
B900 Others in Subjects allied to Medicine
C600 Sports Science
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Rachel Branson
Date Deposited: 27 Oct 2020 09:50
Last Modified: 31 Jul 2021 15:34
URI: http://nrl.northumbria.ac.uk/id/eprint/44597

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics