Poor sleep quality and lipid profile in a rural cohort (The Baependi Heart Study)

Geovanini, Glaucylara Reis, Lorenzi-Filho, Geraldo, de Paula, Lilian K., Oliveira, Camila Maciel, de Oliveira Alvim, Rafael, Beijamini, Felipe, Negrão, André Brooking, von Schantz, Malcolm, Knutson, Kristen L., Krieger, José Eduardo and Pereira, Alexandre Costa (2019) Poor sleep quality and lipid profile in a rural cohort (The Baependi Heart Study). Sleep Medicine, 57. pp. 30-35. ISSN 1389-9457

Poor Sleep Quality and Lipid Profile in a Rural Cohort (The Baependi Heart Study) AAM.pdf - Accepted Version
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Official URL: https://doi.org/10.1016/j.sleep.2018.12.028


Aim: To test the association between cardiometabolic risk factors and subjective sleep quality assessed by the Pittsburgh sleep quality index (PSQI), independent of obstructive sleep apnea (OSA) and sleep duration. Methods: A total of 573 participants from the Baependi Heart Study, a rural cohort from Brazil, completed sleep questionnaires and underwent polygraphy for OSA evaluation. Multivariable linear regression analysis tested the association between cardiovascular risk factors (outcome variables) and sleep quality measured by PSQI, adjusting for OSA and other potential confounders (age, sex, race, salary/wage, education, marital status, alcohol intake, obesity, smoking, hypertension, and sleep duration). Results: The sample mean age was 43 ± 16 years, 66% were female, and mean body mass index (BMI) was 26 ± 5 kg/m 2 . Only 20% were classified as obese (BMI ≥30). Overall, 50% of participants reported poor sleep quality as defined by a PSQI score ≥5. A high PSQI score was significantly associated with higher very-low-density lipoprotein (VLDL) cholesterol levels (beta = 0.392, p = 0.012) and higher triglyceride levels (beta = 0.017, p = 0.006), even after adjustments, including the apnea–hypopnea index. Further adjustments accounting for marital status, alcohol intake, and medication use did not change these findings. No significant association was observed between PSQI scores and glucose or blood pressure. According to PSQI components, sleep disturbances (beta = 1.976, p = 0.027), sleep medication use (beta = 1.121, p = 0.019), and daytime dysfunction (beta = 1.290, p = 0.024) were significantly associated with higher VLDL serum levels. Only the daytime dysfunction domain of the PSQI components was significantly associated with higher triglyceride levels (beta = 0.066, p = 0.004). Conclusion: Poorer lipid profile was independently associated with poor sleep quality, assessed by the PSQI questionnaire, regardless of a normal sleep duration and accounting for OSA and socio-economic status.

Item Type: Article
Additional Information: Funding Information: The authors wish to thank the Municipal Council of Baependi for logistical support and assistance with field work, the dedicated staff at the field station and the participants of the study. This work was supported by the awards from FAPESP to A.C.P. and J.E.K. (grants 2007/58150-7 , 2010/51010-8 , 2011/05804-5 , 2013/17368-0 ), from CNPq to A.C.P., J.E.K., and M.v.S. ( 150653/2008-5 , 481304/2012-6 , and 400791/2015-5 ), a scholarship from CNPq to GRG (project number: 405153/2012-0 ) and PROADI/Hospital Samaritano.
Uncontrolled Keywords: Lipids, Obstructive sleep apnea, Pittsburgh sleep quality index, PSQI, Sleep quality, Very-low density lipoprotein cholesterol
Subjects: B900 Others in Subjects allied to Medicine
C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Rachel Branson
Date Deposited: 26 Aug 2021 13:12
Last Modified: 26 Aug 2021 13:15
URI: http://nrl.northumbria.ac.uk/id/eprint/47010

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