Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study

Domschke, Katharina, Taporoski, Tâmara P., Negrão, André B., Horimoto, Andréa R. V. R., Duarte, Nubia E., Alvim, Rafael O., de Oliveira, Camila M., Krieger, José E., von Schantz, Malcolm, Vallada, Homero and Pereira, Alexandre C. (2015) Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study. PLoS ONE, 10 (12). e0144255. ISSN 1932-6203

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To investigate the phenotypic and genetic overlap between anxiety and depression symptoms in an admixed population from extended family pedigrees. Participants (n = 1,375) were recruited from a cohort of 93 families (mean age±SD 42±16.3, 57% female) in the rural town of Baependi, Brazil. The Hospital Anxiety and Depression Scale (HADS) was used to assess depression and anxiety symptoms. Heritability estimates were obtained by an adjusted variance component model. Bivariate analyses were performed to obtain the partition of the covariance of anxiety and depression into genetic and environmental components, and to calculate the genetic contribution modulating both sets of symptoms. Anxiety and depression scores were 7.49±4.01 and 5.70±3.82, respectively. Mean scores were affected by age and were significantly higher in women. Heritability for depression and anxiety, corrected for age and sex, were 0.30 and 0.32, respectively. Significant genetic correlations (ρg = 0.81) were found between anxiety and depression scores; thus, nearly 66% of the total genetic variance in one set of symptoms was shared with the other set. Our results provided strong evidence for a genetic overlap between anxiety and depression symptoms, which has relevance for our understanding of the biological basis of these constructs and could be exploited in genome-wide association studies.

Item Type: Article
Additional Information: Funding information: This study was supported by grants from Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP, 2013/17368-0, to ACP), from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, 400791/2014-5), Special Visiting Scientist grant to HV on behalf of MvS, and from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Programa de Excelência (CAPES-PROEX, to TPT and 1322/08 to ABN). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Subjects: B900 Others in Subjects allied to Medicine
C100 Biology
C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Rachel Branson
Date Deposited: 27 Aug 2021 08:03
Last Modified: 27 Aug 2021 08:15

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