Absence of morningness alleles in non-European populations

Emmanuel, Paul and von Schantz, Malcolm (2018) Absence of morningness alleles in non-European populations. Chronobiology International, 35 (12). pp. 1758-1761. ISSN 0742-0528

Absence of morningness alleles in non-European populations.pdf - Accepted Version

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Official URL: https://doi.org/10.1080/07420528.2018.1506928


In spite of suspected circadian differences between different ancestral groups, most human studies have used individuals of European descent. This also applies to three recent genome-wide association studies (GWAS), which pinpointed a number of chronotype loci. We investigated the distribution of these hits in different 1000 Genomes populations. We found 6 out of the 41 alleles previously identified by GWAS in European participants (in the genes RGS16, PER2 and AK5 and between the genes APH1A and CA14) to be absent from some non-European population groups. This highlights the need for ancestral diversity in circadian research and may reflect differences affecting the phenotype of individuals of East Asian ancestry.

Item Type: Article
Uncontrolled Keywords: Chronotype, circadian rhythms, diurnal preference, genetics genome-wide association studies
Subjects: B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: John Coen
Date Deposited: 27 Aug 2021 09:09
Last Modified: 27 Aug 2021 09:15
URI: http://nrl.northumbria.ac.uk/id/eprint/47016

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