Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes

Polhemus, Ashley, Ortiz, Laura Delgado, Brittain, Gavin, Chynkiamis, Nikolaos, Salis, Francesca, Gaßner, Heiko, Gross, Michaela, Kirk, Cameron, Rossanigo, Rachele, Taraldsen, Kristin, Balta, Diletta, Breuls, Sofie, Buttery, Sara, Cardenas, Gabriela, Endress, Christoph, Gugenhan, Julia, Keogh, Alison, Kluge, Felix, Koch, Sarah, Micó-Amigo, M. Encarna, Nerz, Corinna, Sieber, Chloé, Williams, Parris, Bergquist, Ronny, de Basea, Magda Bosch, Buckley, Ellen, Hansen, Clint, Mikolaizak, A. Stefanie, Schwickert, Lars, Scott, Kirsty, Stallforth, Sabine, van Uem, Janet, Vereijken, Beatrix, Cereatti, Andrea, Demeyer, Heleen, Hopkinson, Nicholas, Maetzler, Walter, Troosters, Thierry, Vogiatzis, Ioannis, Yarnall, Alison, Becker, Clemens, Garcia-Aymerich, Judith, Leocani, Letizia, Mazzà, Claudia, Rochester, Lynn, Sharrack, Basil, Frei, Anja, Puhan, Milo and Mobilise-D, (2021) Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes. npj Digital Medicine, 4 (1). p. 149. ISSN 2398-6352

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Physical mobility is essential to health, and patients often rate it as a high-priority clinical outcome. Digital mobility outcomes (DMOs), such as real-world gait speed or step count, show promise as clinical measures in many medical conditions. However, current research is nascent and fragmented by discipline. This scoping review maps existing evidence on the clinical utility of DMOs, identifying commonalities across traditional disciplinary divides. In November 2019, 11 databases were searched for records investigating the validity and responsiveness of 34 DMOs in four diverse medical conditions (Parkinson's disease, multiple sclerosis, chronic obstructive pulmonary disease, hip fracture). Searches yielded 19,672 unique records. After screening, 855 records representing 775 studies were included and charted in systematic maps. Studies frequently investigated gait speed (70.4% of studies), step length (30.7%), cadence (21.4%), and daily step count (20.7%). They studied differences between healthy and pathological gait (36.4%), associations between DMOs and clinical measures (48.8%) or outcomes (4.3%), and responsiveness to interventions (26.8%). Gait speed, step length, cadence, step time and step count exhibited consistent evidence of validity and responsiveness in multiple conditions, although the evidence was inconsistent or lacking for other DMOs. If DMOs are to be adopted as mainstream tools, further work is needed to establish their predictive validity, responsiveness, and ecological validity. Cross-disciplinary efforts to align methodology and validate DMOs may facilitate their adoption into clinical practice.

Item Type: Article
Additional Information: Funding information: The Mobilise-D project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement no. 820820. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation program and the European Federation of Pharmaceutical Industries and Associations (EFPIA). This publication reflects the authors’ views and neither IMI nor the European Union, EFPIA, or any Associated Partners are responsible for any use that may be made of the information contained herein. H.D. is a postdoctoral research fellow of the FWO-Flanders. ISGlobal acknowledges support from the Spanish Ministry of Science, Innovation, and Universities through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
Subjects: A300 Clinical Medicine
B100 Anatomy, Physiology and Pathology
C600 Sports Science
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Rachel Branson
Date Deposited: 25 Oct 2021 10:22
Last Modified: 25 Oct 2021 10:30
URI: http://nrl.northumbria.ac.uk/id/eprint/47546

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