Individual differences and diversity in human physiological responses to light

Spitschan, Manuel and Santhi, Nayantara (2022) Individual differences and diversity in human physiological responses to light. EBioMedicine, 75. p. 103640. ISSN 2352-3964

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Abstract

Exposure to light affects our physiology and behaviour through a pathway connecting the retina to the circadian pacemaker in the hypothalamus – the suprachiasmatic nucleus (SCN). Recent research has identified significant individual differences in the non-visual effects of light,mediated by this pathway. Here, we discuss the fundamentals and individual differences in the non-visual effects of light. We propose a set of actions to improve our evidence database to be more diverse: understanding systematic bias in the evidence base, dedicated efforts to recruit more diverse participants, routine deposition and sharing of data, and development of data standards and reporting guidelines.

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