Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing

Chen, Xingmei, Zhang, Jun, Chen, Guangda, Xue, Yu, Zhang, Jiajun, Liang, Xiangyu, Lei, Iek Man, Lin, Jingsen, Xu, Bin and Liu, Ji (2022) Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing. Advanced Functional Materials, 32 (29). p. 2202285. ISSN 1616-301X

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Official URL: https://doi.org/10.1002/adfm.202202285

Abstract

Hydrogel bioadhesives have emerged as one of the most promising alternatives to sutures and staples for wound sealing and repairing, owing to their unique advantages in biocompatibility, mechanical compliance and minimally invasive manipulation. However, only a few hydrogel bioadhesives have been successfully used for gastric perforation repairing, due to their undesirable swelling when in direct contacting with extremely acidic gastric fluids, thereby accompanying with a graduallydeteriorated adhesion performance. Herein, we develop an acid-tolerant hydrogels (ATGels) bioadhesive, which integrates two distinct components, an acid-tolerant hydrogel substrate and an adhesive polymer brush layer. The ATGels bioadhesive could form instant, atraumatic, fluid-tight and sutureless sealing of gastric perforation, and enable robust biointerfaces in direct contact with gastric fluids, addressing the key limitations with sutures and commercially-available tissue adhesives. Moreover, in vivo investigation on gastric perforation of rat model validates the proposed acid-tolerant bioadhesion, and identifies the mechanisms for accelerated gastric perforation repairing through alleviated inflammation, which suppressed fibrosis and enhanced angiogenesis.

Item Type: Article
Additional Information: Funding information: J.L. acknowledges the research startup grant from Shenzhen municipal government (Y01336223) and the research startup grant from SUSTech (Y01336123) ), and the financial support by MechERE Centers at MIT and SUSTech (Y01346002). This work was also supported in part by the Science, Technology and Innovation Commission of Shenzhen Municipality (ZDSYS20200811143601004), Basic and Applied Basic Research Foundation of Guangdong Province (2020A1515110288) and the Basic Research Program of Shenzhen (JCYJ20210324105211032).
Uncontrolled Keywords: biointerface, gastric perforation, hydrogel bioadhesives, robustness, swelling resistance
Subjects: H800 Chemical, Process and Energy Engineering
Department: Faculties > Engineering and Environment > Mechanical and Construction Engineering
Depositing User: Rachel Branson
Date Deposited: 31 Mar 2022 11:14
Last Modified: 04 Aug 2022 14:15
URI: http://nrl.northumbria.ac.uk/id/eprint/48791

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