SPEAR: Systematic ProtEin AnnotatoR

Crown, Matthew, Teruel, Natalia, Najmanovich, Rafael and Bashton, Matthew (2022) SPEAR: Systematic ProtEin AnnotatoR. Bioinformatics, 38 (15). pp. 3827-3829. ISSN 1367-4803

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Abstract

Summary
We present SPEAR, a lightweight and rapid SARS-CoV-2 variant annotation and scoring tool, for identifying mutations contributing to potential immune escape and transmissibility (ACE2 binding) at point of sequencing. SPEAR can be used in the field to evaluate genomic surveillance results in real-time and features a powerful interactive data visualisation report.

Availability and implementation
SPEAR and documentation are freely available on GitHub: https://github.com/m-crown/SPEAR and is implemented in Python and installable via Conda environment.

Supplemental
Supplementary data are available at Bioinformatics online.

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