A simplified three-dimensional numerical simulation approach for surface acoustic wave tweezers

Liu, Lizhu, Zhou, Jian, Tan, Kaitao, Zhang, Hui, Yang, Xin, Duan, Huigao and Fu, Yong Qing (2022) A simplified three-dimensional numerical simulation approach for surface acoustic wave tweezers. Ultrasonics, 125. p. 106797. ISSN 0041-624X

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Official URL: https://doi.org/10.1016/j.ultras.2022.106797


Standing surface acoustic waves (SSAWs) have been extensively used as acoustic tweezers to manipulate, transport, and separate microparticles and biological cells in a microscale fluidic environment, with great potentials for biomedical sensing, genetic analysis, and therapeutics applications. Currently, there lacks an accurate, reliable, and efficient three-dimensional (3D) modeling platform to simulate behaviors of micron-size particles/cells in acoustofluidics, which is crucial to provide the guidance for the experimental studies. The major challenge for achieving this is the computational complexity of 3D modeling. Herein, a simplified but effective 3D SSAW microfluidic model was developed to investigate the separation and manipulation of particles. This model incorporates propagation attenuation of the surface waves to increase the modeling accuracy, while simplifies the modeling of piezoelectric substrates and the wall of microchannel by determining the effective propagation region of the substrate. We have simulated the SSAWs microfluidics device, and systematically analyzed effects of voltage, tilt angle, and flow rate on the separation of the particles under the SSAWs. The obtained simulation results are compared with those obtained from the experimental studies, showing good agreements. This simplified modeling platform could become a convenient tool for acoustofluidic research.

Item Type: Article
Additional Information: Funding information: This work was supported by the General Program of National Natural Science Foundation of China (NSFC No.52075162), The Innovation Leading Program of New and High-tech Industry of Hunan Province(2020GK2015, 2021GK4014),The Natural Science Foundation of Hunan Province (2021JJ20018), Joint fund of the Ministry of Education (Young talents), the Key Research Project of Guangdong Province (2020B0101040002), the Natural Science Foundation of Changsha (kq2007026), the Engineering Physics and Science Research Council of UK (EPSRC EP/P018998/1) and International Exchange Grant (IEC/NSFC/201078) through Royal Society and the NSFC.
Uncontrolled Keywords: Acoustic tweezers, Microfluidics, Particle separation, Numerical simulation
Subjects: F300 Physics
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: John Coen
Date Deposited: 30 Jun 2022 11:52
Last Modified: 30 Jun 2023 08:00
URI: https://nrl.northumbria.ac.uk/id/eprint/49423

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