Plasma nervonic acid levels were negatively associated with attention levels in community-living older adults in New Zealand

de Seymour, Jamie V, Beck, Kathryn L, Conlon, Cathryn A, von Hurst, Pamela R, Mumme, Karen D, Haskell-Ramsay, Crystal and Jones, Mary Beatrix (2022) Plasma nervonic acid levels were negatively associated with attention levels in community-living older adults in New Zealand. Metabolomics, 18 (8). p. 54. ISSN 1573-3890

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The global population is aging. Preserving function and independence of our aging population is paramount. A key component to maintaining independence is the preservation of cognitive function. Metabolomics can be used to identify biomarkers of cognition before noticeable deterioration. Our study investigated the plasma metabolome of 332 community-living New Zealanders between 65 and 74 years of age, using gas chromatography-mass spectrometry. Six cognitive domains were assessed. Of the 123 metabolites identified using an in-house mass spectral libraries of standards, nervonic acid had a significant, inverse association with the attention domain (P-value = 1.52E− 4; FDR = 0.019), after adjusting for covariates (apolipoprotein E -ε4 genotype, sex, body fat percentage (standardised by sex), age, education, deprivation index, physical activity, metabolic syndrome, polypharmacy, smoking status, and alcohol intake) and multiple testing. Attention is defined as the ability to concentrate on selected aspects of the environment while ignoring other stimuli. This is the first study to identify nervonic acid as a potential biomarker of attention in older adults. Future research should confirm this association in a longitudinal study.

Item Type: Article
Additional Information: Funding Information: This work was supported by the Health Research Council of New Zealand [Emerging Researcher Grant 17/566 - Beck]; the University of Auckland [Department of Statistics Faculty Research Development Fund – Jones]; and Lottery Health New Zealand [Postdoctoral Research Fellowship – de Seymour]. The funders were not involved in the design of this study, in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Open Access funding enabled and organized by CAUL and its Member Institutions.
Uncontrolled Keywords: Cognition, Healthy aging, Mass spectrometry, Metabolite, Metabolomics
Subjects: A300 Clinical Medicine
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Rachel Branson
Date Deposited: 03 Aug 2022 10:42
Last Modified: 03 Aug 2022 10:45

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