Ultra-low Ultraviolet Radiation in Office Lighting Can Moderate Seasonal Vitamin D Cycle: A Pilot Study

Webb, Ann R., Van Der Zande, Bianca M.I., Kift, Richard C., O’Neil, Helen, Lin, Nan and Wright, David (2022) Ultra-low Ultraviolet Radiation in Office Lighting Can Moderate Seasonal Vitamin D Cycle: A Pilot Study. Anticancer Research, 42 (10). pp. 5101-5106. ISSN 0250-7005

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Official URL: https://doi.org/10.21873/anticanres.16020


Background/Aim: Ultraviolet-B (UV-B) radiation initiates vitamin D synthesis in the skin, making sun exposure a major source of vitamin D. We aimed to determine whether office lighting containing ultra-low levels of UV-B radiation could modify the winter decline in vitamin D status in the UK, while being safe and well tolerated.

Patients and Methods: Twenty commercial office desk lamps were modified with the addition of UV-B LEDs. Ten hospital office administrative staff received UV-modified lamps with UV-on, and 10 staff received identical placebo lamps with UV switched off, in a double-blind, cross-over pilot study during the winter of 2021/22. Circulating 25-hydroxyvitamin D [25(OH)D] was measured every 4 weeks for 20 weeks: at baseline and during an 8-week trial period, 4-week washout, and a cross-over 8-week trial period.

Results: The linear regression combining the complete datasets for phase 1 and 2 of the trial showed that an 8-week UV light intervention significantly increased 25OHD by 7.13 nmol/l with a p-Value=0.02, compared to the placebo group. Similar results were confirmed by cross-over analyses using the datasets of those completing both phases of the trial both with and without using the inverse probability weighing method to handle dropouts.

Conclusion: The UV-B-modified lighting was well-tolerated and safe with weekly doses of UV-B of 0.5 - 0.9 Standard Erythema Dose [SED=100 Jm -2 erythema weighted UV radiation] measured at chest level. This ultra-low dosing was effective in reducing the winter decline in vitamin D status.

Item Type: Article
Uncontrolled Keywords: Ultraviolet Radiation, vitamin D, 25(OH)D, winter, cross-over trial, office lighting
Subjects: B900 Others in Subjects allied to Medicine
C800 Psychology
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: John Coen
Date Deposited: 24 Oct 2022 10:12
Last Modified: 24 Oct 2022 10:15
URI: https://nrl.northumbria.ac.uk/id/eprint/50433

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