Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV)

Redman, Kirsten N., O'Brien, Katie, Ruiz, Francieli S., Rae, Dale E., Gómez-Olivé, Francesc Xavier, von Schantz, Malcolm and Scheuermaier, Karine (2022) Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV). Journal of Pineal Research. e12838. ISSN 0742-3098 (In Press)

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Official URL: https://doi.org/10.1111/jpi.12838

Abstract

The increasing number of people living with human immunodeficiency virus, HIV, (PLWH) have an elevated incidence of risk for noncommunicable comorbidities, the aetiology of which remains incompletely understood. While sleep disturbances are often reported in PLWH, it is unknown to what extent they relate to changes in the circadian and/or sleep homeostatic processes. We studied the relationship between sleep characteristics, circadian phase, and HIV status in older adults from the HAALSI (Health and Ageing in Africa: a Longitudinal Study of an INDEPTH Community in South Africa) subsample of the Agincourt Health and Demographic Surveillance System in South Africa (n = 187, 36 human immunodeficiency virus positive [HIV+], age: 66.7 ± 11.5 years, range 45—93 years), where HIV prevalence is high and (in contrast to the global north) does not associate significantly with potentially confounding behavioural differences. In participants with valid actigraphy data (n = 172), regression analyses adjusted for age and sex indicated that HIV+ participants had slightly later sleep onset (β = .16, p = .039), earlier sleep offset times (β = −.16, p = .049) and shorter total sleep times (β = −.20, p = .009) compared to the HIV negative (HIV−) participants. In a subset of participants (n = 51, 11 HIV+), we observed a later dim light melatonin onset (DLMO) in HIV+ (21:16 ± 01:47) than in HIV− (20:06 ± 00:58) participants (p = .006). This substantial difference remained when adjusted for age and sex (β = 1.21; p = .006). In 36 participants (6 HIV+) with DLMO and actigraphy data, median phase angle of entrainment was −6 min in the HIV+ group and +1 h 25 min in the HIV− group. DLMO time correlated with sleep offset (ρ = 0.47, p = .005) but not sleep onset (ρ = −0.086, p = .623). Collectively, our data suggest that the sleep phase occurred earlier than what would be biologically optimal among the HIV+ participants. This is the first report of a mistimed circadian phase in PLWH, which has important potential implications for their health and well-being, especially given the well-established relationships between circadian asynchrony and sleep deprivation with poorer health outcomes.

Item Type: Article
Additional Information: Funding information: We are grateful to the late Audrey Khosa, Shingirai Chipungu, and the MRC/Wits Agincourt Research Unit staff for their work collecting the data and the samples for the study and to Ms Monica Gomes at the School of Physiology of the University of the Witwatersrand for technical assistance. We also thank the members of the Agincourt community for their participation in the study. This work as supported by the Academy of Medical Sciences, Grant/Award Numbers: AF006\1004 and NIF004\1030 and the National Research Foundation's DST-NRF Innovation Doctoral Scholarship for Kirsten N. Redman.
Uncontrolled Keywords: circadian rhythm disorders, human immunodeficiency virus, neuroendocrinology
Subjects: B100 Anatomy, Physiology and Pathology
C500 Microbiology
C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Elena Carlaw
Date Deposited: 31 Oct 2022 15:38
Last Modified: 07 Nov 2022 09:12
URI: https://nrl.northumbria.ac.uk/id/eprint/50493

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