Genomic and phylogenomic insights into the family Streptomycetaceae lead to the proposal of six novel genera

Madhaiyan, Munusamy, Saravanan, Venkatakrishnan Sivaraj, See-Too, Wah-Seng, Volpiano, Camila Gazolla, Sant’Anna, Fernando Hayashi, Faria da Mota, Fábio, Sutcliffe, Iain, Sangal, Vartul, Passaglia, Luciane Maria Pereira and Rosado, Alexandre Soares (2022) Genomic and phylogenomic insights into the family Streptomycetaceae lead to the proposal of six novel genera. International Journal of Systematic and Evolutionary Microbiology, 72 (10). 005570. ISSN 1466-5026

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The family Streptomycetaceae is a large and diverse family within the phylum Actinomycetota . The members of the family are known for their ability to produce medically important secondary metabolites, notably antibiotics. In this study, 19 type strains showing low 16S rRNA gene similarity (<97.3 %) to other members of the family Streptomycetaceae were identified and their high genetic diversity was reflected in a phylogenomic analysis using conserved universal proteins. This analysis resulted in the identification of six distinct genus-level clades, with two separated from the genus Streptacidiphilus and four separated from the genus Streptomyces . Compared with members of the genera Streptacidiphilus and Streptomyces , average amino acid identity (AAI) analysis of the novel genera identified gave values within the range of 63.9–71.3 %, as has been previously observed for comparisons of related but distinct bacterial genera. The whole-genome phylogeny was reconstructed using PhyloPhlAn 3.0 based on an optimized subset of conserved universal proteins, the results of AAI and percentage of conserved proteins (POCP) analyses indicated that these phylogenetically distinct taxa may be assigned to six novel genera, namely Actinacidiphila gen. nov., Mangrovactinospora gen. nov., Peterkaempfera gen. nov., Phaeacidiphilus gen. nov., Streptantibioticus gen. nov. and Wenjunlia gen. nov.

Item Type: Article
Subjects: C500 Microbiology
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Elena Carlaw
Date Deposited: 04 Nov 2022 12:15
Last Modified: 04 Nov 2022 12:15

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