The Idiopathic Pulmonary Fibrosis-associated single nucleotide polymorphism rs35705950 is transcribed in a MUC5B Promoter Associated Long Non-Coding RNA (AC061979.1)

Neatu, Ruxandra, Enekwa, Ifeanyi, Thompson, Dean, Schwalbe, Ed, Fois, Giorgio, Abdelaal, Gina, Veuger, Stephany, Frick, Manfred, Braubach, Peter and Moschos, Sterghios (2022) The Idiopathic Pulmonary Fibrosis-associated single nucleotide polymorphism rs35705950 is transcribed in a MUC5B Promoter Associated Long Non-Coding RNA (AC061979.1). Non-coding RNA, 8 (6). p. 83. ISSN 2311-553X

[img]
Preview
Text
Neatu_et_al_Revised_MS_Final.pdf - Accepted Version
Available under License Creative Commons Attribution 4.0.

Download (2MB) | Preview
[img]
Preview
Text
ncrna-08-00083.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (2MB) | Preview
Official URL: https://doi.org/10.3390/ncrna8060083

Abstract

LncRNAs are involved in regulatory processes in the human genome, including gene expression. The rs35705950 SNP, previously associated with IPF, overlaps the recently annotated lncRNA AC061979.1, a 1,712 nucleotide transcript located within the MUC5B promoter at chromosome 11p15.5. To document the expression pattern of the transcript, we processed 3.9 TBases of publicly available RNA-SEQ data across 27 independent studies involving lung airway epithelial cells. Epithelial lung cells showed expression of this putative pancRNA. The findings were independently validated in cell lines and primary cells. The rs35705950 is found within a conserved region (from fish to primates) within the expressed sequence indicating functional importance. These results implicate the rs35705950-containing AC061979.1 pancRNA as a novel component of the MUC5B expression control minicircuitry.

Item Type: Article
Uncontrolled Keywords: non-coding RNA, MUC5B, IPF, rs35705950
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: John Coen
Date Deposited: 01 Dec 2022 11:15
Last Modified: 09 Dec 2022 03:30
URI: https://nrl.northumbria.ac.uk/id/eprint/50786

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics