Regulating eEF2 and eEF2K in skeletal muscle by exercise

Salimi, Kia, Alvandi, Masoomeh, Pirouz, Mahdi, Rakhshan, Kamran and Howatson, Glyn (2023) Regulating eEF2 and eEF2K in skeletal muscle by exercise. Archives of Physiology and Biochemistry. ISSN 1381-3455 (In Press)

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Official URL: https://doi.org/10.1080/13813455.2023.2164898

Abstract

Skeletal muscle is a flexible and adaptable tissue that strongly responds to exercise training. The skeletal muscle responds to exercise by increasing muscle protein synthesis (MPS) when energy is available. One of protein synthesis’s major rate-limiting and critical regulatory steps is the translation elongation pathway. The process of translation elongation in skeletal muscle is highly regulated. It requires elongation factors that are intensely affected by various physiological stimuli such as exercise and the total available energy of cells. Studies have shown that exercise involves the elongation pathway by numerous signalling pathways. Since the elongation pathway, has been far less studied than the other translation steps, its comprehensive prospect and quantitative understanding remain in the dark. This study highlights the current understanding of the effect of exercise training on the translation elongation pathway focussing on the molecular factors affecting the pathway, including Ca2+, AMPK, PKA, mTORC1/P70S6K, MAPKs, and myostatin. We further discussed the mode and volume of exercise training intervention on the translation elongation pathway.

Item Type: Article
Uncontrolled Keywords: Skeletal muscle, exercise training, elongation pathway
Subjects: C600 Sports Science
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Rachel Branson
Date Deposited: 03 Jan 2023 09:03
Last Modified: 18 Jan 2023 17:15
URI: https://nrl.northumbria.ac.uk/id/eprint/51010

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