A human Phase I/IIa malaria challenge trial of a polyprotein malaria vaccine

Porter, David, Thompson, Fiona, Berthoud, Tamara, Hutchings, Claire, Andrews, Laura, Biswas, Sumi, Poulton, Ian, Prieur, Eric, Correa, Simon, Rowland, Rosalind, Lang, Trudie, Williams, Jack, Gilbert, Sarah, Sinden, Robert, Todryk, Stephen and Hill, Adrian (2011) A human Phase I/IIa malaria challenge trial of a polyprotein malaria vaccine. Vaccine, 29 (43). pp. 7514-7522. ISSN 0264-410X

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Abstract

We examined the safety, immunogenicity and efficacy of a prime-boost vaccination regime involving two poxvirus malaria subunit vaccines, FP9-PP and MVA-PP, expressing the same polyprotein consisting of six pre-erythrocytic antigens from Plasmodium falciparum.

Following safety assessment of single doses, 15 volunteers received a heterologous prime-boost vaccination regime and underwent malaria sporozoite challenge. The vaccines were safe but interferon-γ ELISPOT responses were low compared to other poxvirus vectors, despite targeting multiple antigens. There was no vaccine efficacy as measured by delay in time to parasitaemia. A number of possible explanations are discussed, including the very large insert size of the polyprotein transgene.

Item Type:	Article
Uncontrolled Keywords:	Heterologous prime-boost, immunology
Subjects:	A100 Pre-clinical Medicine C900 Others in Biological Sciences
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Ay Okpokam
Date Deposited:	28 Mar 2012 13:42
Last Modified:	12 Oct 2019 18:26
URI:	http://nrl.northumbria.ac.uk/id/eprint/5907

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