Expression of the MtsA lipoprotein of Streptococcus agalactiae A909 is regulated by manganese and iron

Bray, Beverley, Sutcliffe, Iain and Harrington, Dean (2009) Expression of the MtsA lipoprotein of Streptococcus agalactiae A909 is regulated by manganese and iron. Antonie van Leeuwenhoek, 95 (1). pp. 101-109. ISSN 0003-6072

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Abstract

Metal ion acquisition and homeostasis are essential for bacterial survival, growth and physiology. A family of metal ion, ABC-type import systems have been identified in Gram-positive bacteria, in which the solute-binding proteins are predicted to be membrane-anchored lipoproteins. The prediction that the MtsA protein of Streptococcus agalactiae A909 is a lipoprotein was confirmed. The expression of MtsA was co-ordinately regulated by the presence of both manganese and ferrous ions suggesting that MtsA may be involved in the uptake of both these ions. MtsA was shown to be expressed at levels of ferrous ions known to be present in amniotic fluid, a growth medium for S. agalactiae during neonatal infection

Item Type:	Article
Uncontrolled Keywords:	Streptococcus agalactiae, Lipoproteins
Subjects:	F100 Chemistry
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	EPrint Services
Date Deposited:	03 Feb 2011 12:02
Last Modified:	31 Jul 2021 08:39
URI:	http://nrl.northumbria.ac.uk/id/eprint/658

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