Matthews, John and Philipson, Pete (2012) Optimal designs for threshold-determining limiting dilution assays. Journal of Statistical Planning and Inference, 142 (6). pp. 1388-1395. ISSN 1873-1171
Full text not available from this repository. (Request a copy)Abstract
In common with other non-linear models, the optimal design for a limiting dilution assay (LDA) depends on the value of the unknown parameter, θ, in the model. Consequently optimal designs cannot be specified unless some assumptions are made about the possible values of θ. If a prior distribution can be specified then a Bayesian approach can be adopted. A proper specification of the Bayesian approach requires the aim of the experiment to be described and quantified through an appropriate utility function. This paper addresses the problem of finding optimal designs for LDAs when the aim is to determine whether θ is above or below a specified threshold, θ0.
Item Type: | Article |
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Uncontrolled Keywords: | Limiting dilution assay, serial dilution assay, optimal design, threshold |
Subjects: | G300 Statistics |
Department: | Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering |
Depositing User: | Pete Philipson |
Date Deposited: | 11 May 2012 12:33 |
Last Modified: | 13 Oct 2019 00:32 |
URI: | http://nrl.northumbria.ac.uk/id/eprint/6941 |
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