Enantioselective detection of l-serine

Stanley, Simon, Percival, Carl, Morel, T., Braithwaite, Alan, Newton, Michael, McHale, Glen and Hayes, Wayne (2003) Enantioselective detection of l-serine. Sensors and Actuators B: Chemical, 89 (1-2). pp. 103-106. ISSN 0925-4005

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Abstract

An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively detect the amino acid L-serine. A highly specific non-covalently imprinted polymer was cast on one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the L-serine was observed as a frequency shift in the QCM with a detection limit of 2 ppb and for concentrations up to 0.4 ppm. The sensor binding is shown to be capable of discrimination between L- and D-stereoisomers of serine as a result of the enantioselectivity of the imprinted binding sites.

Item Type:	Article
Uncontrolled Keywords:	molecular imprinted polymers (MIPs), quartz crystal microbalance (QCM), sensor
Subjects:	F100 Chemistry F300 Physics H600 Electronic and Electrical Engineering
Department:	Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User:	Glen McHale
Date Deposited:	29 Aug 2012 15:22
Last Modified:	12 Oct 2019 19:05
URI:	http://nrl.northumbria.ac.uk/id/eprint/8352

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