Enantioselective detection of l-serine

Stanley, Simon, Percival, Carl, Morel, T., Braithwaite, Alan, Newton, Michael, McHale, Glen and Hayes, Wayne (2003) Enantioselective detection of l-serine. Sensors and Actuators B: Chemical, 89 (1-2). pp. 103-106. ISSN 0925-4005

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Official URL: http://dx.doi.org/10.1016/S0925-4005(02)00449-5


An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively detect the amino acid L-serine. A highly specific non-covalently imprinted polymer was cast on one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the L-serine was observed as a frequency shift in the QCM with a detection limit of 2 ppb and for concentrations up to 0.4 ppm. The sensor binding is shown to be capable of discrimination between L- and D-stereoisomers of serine as a result of the enantioselectivity of the imprinted binding sites.

Item Type: Article
Uncontrolled Keywords: molecular imprinted polymers (MIPs), quartz crystal microbalance (QCM), sensor
Subjects: F100 Chemistry
F300 Physics
H600 Electronic and Electrical Engineering
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: Glen McHale
Date Deposited: 29 Aug 2012 15:22
Last Modified: 12 Oct 2019 19:05
URI: http://nrl.northumbria.ac.uk/id/eprint/8352

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