Validation of a model of regulation in the tryptophan operon against multiple experiment data using global optimisation

Kim, Jongrae, Kim, Jung-Su, Postlethwaite, Ian, Heslop-Harrison, Pat and Bates, Declan (2009) Validation of a model of regulation in the tryptophan operon against multiple experiment data using global optimisation. In: Proceedings of the ICCAS-SICE, 2009. ICROS-SICE International Joint Conference . IEEE Xplore, Piscataway, NJ, pp. 209-211. ISBN 978-4907764340

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Abstract

This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the model output and experimental data was demonstrated, since very little information is currently available to guide the selection of parameter values for the models. This paper presents a model validating method using both multiple experimental data and global optimization.

Item Type:	Book Section
Additional Information:	ICCAS-SICE 2009 conference from 18-21 August 2009 held in Fukouka, Japan
Subjects:	H600 Electronic and Electrical Engineering
Department:	Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User:	Sarah Howells
Date Deposited:	17 Oct 2012 15:49
Last Modified:	12 Oct 2019 22:29
URI:	http://nrl.northumbria.ac.uk/id/eprint/9740

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