Turner, Daniel, Walker, Mark, Luzio, Stephen, Bain, Stephen, Richards, A., Rhydderch, Danielle, Martin, R., Kilduff, Liam, Campbell, Matthew, West, Dan and Bracken, Richard (2016) An algorithm that delivers an individualized rapid-acting insulin dose after morning resistance exercise counters post-exercise hyperglycaemia in type 1 diabetes patients: a randomized pilot study. Diabetic Medicine, 33 (4). pp. 506-510. ISSN 1464-5491
Full text not available from this repository. (Request a copy)Abstract
Aims - To develop an algorithm that delivers an individualized dose of rapid-acting insulin after morning resistance exercise to counter post-exercise hyperglycaemia in individuals with Type 1 diabetes.
Methods - Eight people with Type 1 diabetes, aged 34 ± 7 years with HbA1c concentrations 72 ± 12 mmol/mol (8.7 ± 1.1%), attended our laboratory on two separate mornings after fasting, having taken their usual basal insulin the previous evening. These people performed a resistance exercise session comprising six exercises for two sets of 10 repetitions at 60% of the maximum amount of force that was generated in one maximal contraction (60% 1RM). In a randomized and counterbalanced order, the participants were administered an individualized dose of rapid-acting insulin (2 ± 1 units, range 0–4 units) immediately after resistance exercise (insulin session) by means of an algorithm or were not administered this (no-insulin session). Venous blood glucose concentrations were measured for 125 min after resistance exercise. Data (mean ± sem values) were analysed using anova (P ≤ 0.05).
Results - Participants had immediate post-resistance exercise hyperglycaemia (insulin session 13.0 ± 1.6 vs. no-insulin session 12.7 ± 1.5 mmol/l; P = 0.834). The decline in blood glucose concentration between peak and 125 min after exercise was greater in the insulin exercise session than in the no-insulin session (3.3 ± 1.0 vs. 1.3 ± 0.4 mmol/l: P = 0.015). There were no episodes of hypoglycaemia (blood glucose <3.9 mmol/l).
Conclusions - Administration of rapid-acting insulin according to an individualized algorithm reduced the hyperglycaemia associated with morning resistance exercise without causing hypoglycaemia in the 2 h post-exercise period in people with Type 1 diabetes.
Item Type: | Article |
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Subjects: | A300 Clinical Medicine B400 Nutrition C600 Sports Science |
Department: | Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation |
Depositing User: | Ay Okpokam |
Date Deposited: | 13 Jul 2015 13:12 |
Last Modified: | 18 Nov 2021 15:55 |
URI: | http://nrl.northumbria.ac.uk/id/eprint/23349 |
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