Hyperthermia Suppresses Post - In Vitro Proliferation and Tumor Growth in Murine Malignant Melanoma and Colon Carcinoma

Mantso, Theodora, Vasileiadis, Stavros, Lampri, Evangeli, Botaitis, Sotiris, Perente, Sebachedin, Simopoulos, Constantinos, Chlichlia, Katerina, Pappa, Aglaia and Panagiotidis, Mihalis (2019) Hyperthermia Suppresses Post - In Vitro Proliferation and Tumor Growth in Murine Malignant Melanoma and Colon Carcinoma. Anticancer Research, 39 (5). pp. 2307-2315. ISSN 0250-7005

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Official URL: http://doi.org/10.21873/anticanres.13347

Abstract

Background: Several studies have highlighted hyperthermia’s ability to enhance the effectiveness of radiation and chemotherapy in various in vitro and in vivo cancer models. Materials and Methods: In vivo murine models of malignant melanoma and colon carcinoma were utilized for demonstrating hyperthermia’s therapeutic effectiveness by examining levels of caspase 3, COX-2 and phospho-H2A.X (Ser139) as endpoints of apoptosis, proliferation and DNA damage respectively. Results: Hyperthermia induced in vitro cytotoxicity in malignant melanoma (B16-F10) and colon carcinoma (CT26) cell lines. In addition, it reduced post-in vitro proliferation and suppression of tumor growth by inducing the expression of caspase-3 and phospho-H2A.X (Ser139) while reducing the expression of COX-2 in both murine cancer models. Conclusion: Hyperthermia can exert therapeutic effectiveness against melanoma and colon carcinoma by inhibiting a number of critical cellular cascades including apoptosis, proliferation and DNA damage.

Item Type: Article
Uncontrolled Keywords: Hyperthermia, malignant melanoma, colon carcinoma, experimental cancer therapeutics, proliferation, apoptosis, DNA damage
Subjects: B100 Anatomy, Physiology and Pathology
C900 Others in Biological Sciences
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 08 May 2019 07:54
Last Modified: 20 May 2019 11:00
URI: http://nrl.northumbria.ac.uk/id/eprint/39210

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