Ascorbate enhances iron uptake into intestinal cells through formation of a FeCl3–ascorbate complex

Thumser, Alfred, Rashed, Aswir Abd, Sharp, Paul and Lodge, John (2010) Ascorbate enhances iron uptake into intestinal cells through formation of a FeCl3–ascorbate complex. Food Chemistry, 123 (2). pp. 281-285. ISSN 0308-8146

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Official URL: http://dx.doi.org/10.1016/j.foodchem.2010.04.031

Abstract

It has been well documented that ascorbate enhances iron uptake, with a proposed mechanism based on reduction to the more absorbable ferrous form. We have performed a study on the effects of ascorbate on ferric iron uptake in the human epithelial Caco-2 cell-line. Ascorbate increased uptake in a concentration-dependent manner with a significant difference between iron uptake and reduction. Uptake kinetics are characteristic of a non-essential activator and the formation of an Fe(3+)-ascorbate complex. This investigation provides evidence that ascorbate enhances the apical uptake of ferric iron into Caco-2 cells through the formation of a Fe(3+)-ascorbate complex.

Item Type: Article
Uncontrolled Keywords: Enterocyte iron uptake, ascorbate, Ferric iron
Subjects: B400 Nutrition
C100 Biology
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Ay Okpokam
Date Deposited: 19 Dec 2011 12:05
Last Modified: 10 Aug 2015 11:41
URI: http://nrl.northumbria.ac.uk/id/eprint/4267

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