Proximicins A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete verrucosispora

Fiedler, Hans-Peter, Bruntner, Christina, Riedlinger, Julia, Bull, Alan, Knutsen, Gjert, Goodfellow, Michael, Jones, Amanda, Maldonado, Luis, Pathom-Aree, Wasu, Beil, Winfried, Schneider, Kathrin, Keller, Simone and Süssmuth, Roderich (2008) Proximicins A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete verrucosispora. Journal of Antibiotics, 61. pp. 158-163. ISSN 0021-8820

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Official URL: http://dx.doi.org/10.1038/ja.2008.125

Abstract

A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown -amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.

Item Type: Article
Subjects: C100 Biology
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrints Services
Date Deposited: 01 Jun 2009 14:18
Last Modified: 10 Aug 2015 11:46
URI: http://nrl.northumbria.ac.uk/id/eprint/95

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