A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

Lauder, Kate, Masci, Domiziana, Toscani, Anita, Al Mekdad, Aya, Black, Gary, Brown, Nicola, Turner, Nicholas J., Luisi, Renzo and Castagnolo, Daniele (2019) A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution. Organic & Biomolecular Chemistry, 17 (40). pp. 8982-8986. ISSN 1477-0520

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Official URL: https://doi.org/10.1039/c9ob01962f

Abstract

A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.

Item Type: Article
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
F100 Chemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Elena Carlaw
Date Deposited: 31 Oct 2019 15:21
Last Modified: 31 Jul 2020 12:45
URI: http://nrl.northumbria.ac.uk/id/eprint/41326

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