The effects of glucose ingestion and glucose regulation on memory performance in older adults with mild cognitive impairment

Riby, Leigh, Marriott, A., Bullock, Robert, Hancock, Jude, Smallwood, Jonathan and McLaughlin, Jennifer (2009) The effects of glucose ingestion and glucose regulation on memory performance in older adults with mild cognitive impairment. European Journal of Clinical Nutrition, 63 (4). pp. 566-571. ISSN 0954-3007

Full text not available from this repository. (Request a copy)

Abstract

Background/Objectives
Previous research investigating the impact of glucose ingestion and/or improvements in glucose regulation has found selective cognitive facilitation on episodic memory tasks in successful ageing and dementia. The present study aimed to extend this research to mild cognitive impairment (MCI).

Subjects/Methods
In a repeated-measures design, 24 older adults with and 24 older adults without MCI performed a battery of memory and attention tasks after 25g of glucose or a sweetness matched placebo. In addition, to assess the impact of individual differences in glucose regulation, blood glucose measurements were taken throughout the testing session.

Results
Consistent with previous research, cognitive facilitation was observed for episodic memory tasks only in both successful ageing and MCI. Older adults with MCI had a similar glucose regulatory response as controls but their fasting levels were elevated. Notably, higher levels of blood glucose were associated with impaired memory performance in both the glucose and placebo conditions. Importantly, both blood glucose and memory performance indices were significant predictors of MCI status.

Conclusions
The utility of glucose supplementation and the use of glucose regulation as a biological marker are discussed in relation to these data.

Item Type:	Article
Subjects:	B400 Nutrition
Department:	Faculties > Health and Life Sciences > Psychology
Depositing User:	EPrint Services
Date Deposited:	07 Mar 2011 13:48
Last Modified:	12 Oct 2019 16:28
URI:	http://nrl.northumbria.ac.uk/id/eprint/2390

Downloads