Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs

Burke, Philip, Chun Wong, Lai, Jenkins, Terence, Knox, Richard, Meikle, Ian and Stanforth, Stephen (2016) Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs. Bioorganic & Medicinal Chemistry Letters, 26 (24). pp. 5851-5854. ISSN 0960-894X

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Abstract

A series of N-nitroarylated-3-chloromethyl-1,2,3,4-tetrahydroisoquinoline derivatives, several of which also possessed a trifluoromethyl substituent, were prepared and assessed as potential nitroaromatic prodrugs. The enzymatic reduction of these compounds and their cytotoxicities were studied. The compounds were cytotoxic, but this is probably not related to their enzymatic reduction.

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