Cellier, Marie, James, Arthur, Orenga, Sylvain, Perry, John, Rasul, Ari and Stanforth, Stephen (2017) Detection of L-alanylaminopeptidase activity in microorganisms using chromogenic self-immolative enzyme substrates. Bioorganic & Medicinal Chemistry Letters, 27 (10). pp. 2102-2106. ISSN 0960-894X
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Official URL: https://doi.org/10.1016/j.bmcl.2017.03.080
Abstract
Three potential chromogenic enzymatic probes, each possessing a self-immolative spacer unit, were synthesised for the purpose of detecting L-alanylaminopeptidase activity in microorganisms. An Alizarin-based probe was the most effective, allowing several species to generate strongly coloured colonies in the presence of metal ions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Chromogenic enzyme substrates; L-alanylaminopeptidase detection; Microorganisms |
| Subjects: | C500 Microbiology C700 Molecular Biology, Biophysics and Biochemistry |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Paul Burns |
| Date Deposited: | 30 Mar 2017 09:45 |
| Last Modified: | 11 Oct 2019 21:19 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/30282 |
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