Estimating the number of UK stroke patients eligible for endovascular thrombectomy

McMeekin, Peter, White, Philip, Martin, James, Price, Christopher, Flynn, Darren and Ford, Gary (2017) Estimating the number of UK stroke patients eligible for endovascular thrombectomy. European Stroke Journal, 2 (4). pp. 319-326. ISSN 2396-9873

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Endovascular thrombectomy (EVT) is a highly effective treatment for acute ischemic stroke due to large arterial occlusion. Routine provision will require major changes in service configuration and workforce. An important first step is to quantify the population of stroke patients that could benefit. We estimated the annual UK population suitable for EVT using standard or advanced imaging (AI) for patient selection.

Patients and Methods:
Evidence from randomised control trials and national registries was combined to estimate UK stroke incidence and define a decision-tree describing the EVT eligible population.

Between 9,620 and 10,920 UK stroke patients (approximately 10% of stroke admissions) would be eligible for EVT annually. The majority (9,140 to 9,620) would present within 4 hours of onset and be suitable for intravenous thrombolysis. Advanced Imaging would exclude 500 patients presenting within 4 hours, but identify an additional 1,310 patients as eligible who present later.

Information from randomised control trials and large registry data provided the evidence criterion for 9 of the 12 decision points. The best available evidence was used for 2 decision-points with sensitivity analyses to determine how key branches of the tree affected estimates. Using the mid-point estimate for eligibility (9.6% of admissions) and assuming national EVT coverage, 4,280 patients would have reduced disability.

A model combining published trials and register data suggests approximately 10% of all stroke admissions in the UK are eligible for EVT. The use of AI based on current published evidence did not have a major impact on overall numbers, but could alter eligibility status for 16% of cases.

Item Type: Article
Additional Information: Funding information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This article presents independent research funded by the National Institute for Health Research (NIHR) under its Programme Grant for Applied Research Programme (RP-PG-1211-20012). MAJ is supported by the NIHR Collaboration for Leadership in Applied Health Research and Care for the South West Peninsula. GAF was supported by an NIHR Senior Investigator award. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the English Department of Health. The work was supported by an unrestricted grant from Medtronic.
Uncontrolled Keywords: thrombectomy; ischemic stroke; advanced imaging; service planning
Subjects: A300 Clinical Medicine
B800 Medical Technology
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Paul Burns
Date Deposited: 25 Sep 2017 08:40
Last Modified: 10 Nov 2021 11:55

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