Ironmonger, Alan, Shipton, Mark, Slater, Fiona, Szeto, Pete, Unthank, Matthew, Alexandre, François-René, Caillet, Catherine and Dousson, Cyril B. (2018) A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus on-route to a key intermediate in the synthesis of GSK2248761A. Tetrahedron Letters, 59 (22). pp. 2154-2156. ISSN 0040-4039
|
Text (Full text)
Ironmonger et al - TetLetsApr18 AAM.pdf - Accepted Version Download (783kB) | Preview |
Abstract
A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus has been developed to access a key intermediate in the synthesis of GSK2248761A. This procedure utilises a soluble chloride source and a cheap readily available chiral auxiliary. The practicality of this transformation is demonstrated on a multi-gram scale.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Asymmetric synthesis; Chiral phosphorus; Dynamic kinetic resolution; GSK2248761A; Phenylglycine methyl ester |
| Subjects: | C700 Molecular Biology, Biophysics and Biochemistry |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Paul Burns |
| Date Deposited: | 04 Jun 2018 09:34 |
| Last Modified: | 01 Aug 2021 12:04 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/34458 |
Actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
