Epigenetics – Potential Contribution to Fetal Programming

Mathers, John C. and McKay, Jill (2009) Epigenetics – Potential Contribution to Fetal Programming. In: ENA Conference Budapest 2007: Early nutrition programming and health outcomes in later life: obesity and beyond, April 2007, Budapest, Hungary.

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Abstract

Whilst the primary DNA sequence sets the limits of potential gene expression, the pattern of gene expression in a given cell under particular circumstances is determined by several factors including the epigenetic marking of the genome. These marks include DNA methylation and post-translational modification of the histones around which DNA is wrapped when packaged in the nucleus. Importantly, these marks are malleable in response to environmental exposures and contribute to phenotypic plasticity in the context of a fixed genotype. There is now proof of principle that maternal diet can have a profound impact on the epigenome and so determine gene expression patterns and health throughout the life-course. Studies of altered epigenetic marking will be of profound importance for mechanistic understanding of the role of nutrition in health but especially for studies of the developmental origins of health.

Item Type:	Conference or Workshop Item (Paper)
Uncontrolled Keywords:	DNA methylation, epigenetics, gene expression, histone decoration
Subjects:	B400 Nutrition C400 Genetics
Department:	Faculties > Health and Life Sciences > Applied Sciences
Related URLs:	Publisher
Depositing User:	Paul Burns
Date Deposited:	03 Sep 2018 11:51
Last Modified:	11 Oct 2019 19:30
URI:	http://nrl.northumbria.ac.uk/id/eprint/35557

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