Sarcopenic obesity and overall mortality: Results from the application of novel models of body composition phenotypes to the National Health and Nutrition Examination Survey 1999–2004

Van Aller, Carla, Lara Gallegos, Jose, Stephan, Blossom, Donini, Lorenzo Maria, Heymsfield, Steven, Katzmarzyk, Peter, Wells, Jonathan, Prado, Carla and Siervo, Mario (2019) Sarcopenic obesity and overall mortality: Results from the application of novel models of body composition phenotypes to the National Health and Nutrition Examination Survey 1999–2004. Clinical Nutrition, 38 (1). pp. 264-270. ISSN 0261-5614

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Abstract

Background/Objectives:There is no consensus on the definition of sarcopenic obesity (SO), resulting ininconsistent associations of SO with mortality risk. We aim to evaluate association of dual energy x-rayabsorptiometry (DXA) SO models with mortality risk in a US adult population (�50 years).Subjects/Methods:The study population consisted of 3577 participants aged 50 years and older from the1999e2004 National Health and Nutrition and Examination Survey with mortality follow-up datathrough December 31, 2011. Difference in survival time in people with and without SO defined by threebody composition DXA models (Model 1: body composition phenotype model; Model 2: Truncal Fat Mass(TrFM)/Appendicular Skeletal Muscle Mass (ASM) ratio model; Model 3: Fat Mass (FM)/Fat Free Mass(FFM) ratio). The differences between the models were assessed by the acceleration failure time model,and expressed as time ratios (TR).Results:Participants age 50e70 years with SO had a significantly decreased survival time, according tothe body composition phenotype model (TR: 0.92; 95% CI: 0.87e0.97), and TrFM/ASM ratio model (TR:0.88; 95% CI: 0.81e0.95). The FM/FFM ratio model did not detect significant differences in survival time.Participants with SO aged 70 years and older did not have a significantly decreased survival time, ac-cording to all three models.Conclusions:A SO phenotype increases mortality risk in people of age 50e70 years, but not in peopleaged 70 years and older. The application of the body composition phenotype and the TrFM/ASM ratiomodels may represent useful diagnostic approaches to improve the prediction of disease and mortalityrisk.

Item Type:	Article
Uncontrolled Keywords:	Sarcopenic obesity, Body composition, Mortality
Subjects:	A300 Clinical Medicine B400 Nutrition
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Elena Carlaw
Date Deposited:	05 Mar 2019 12:50
Last Modified:	10 Oct 2019 21:02
URI:	http://nrl.northumbria.ac.uk/id/eprint/38300

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