The impact of dietary fibres on the physiological processes of the large intestine

Gill, Saloni, Chater, Peter I., Wilcox, Matthew D., Pearson, Jeffrey P. and Brownlee, Iain A. (2018) The impact of dietary fibres on the physiological processes of the large intestine. Bioactive Carbohydrates and Dietary Fibre, 16. pp. 62-74. ISSN 2212-6198

Full text not available from this repository. (Request a copy)
Official URL:


No endogenous secretion of digestive enzymes occurs within the human large intestine, yet this region of the gut still has an important role in the absorption of water and a range of nutrients. In parallel, the large intestine must also cope with a high load of micro-organisms and an increasing concentration of potentially toxic agents. The duality of these roles (facilitating absorption while effectively partitioning damaging luminal agents) is vital to the proper functioning of the large intestine. The effectors of these roles are the smooth muscle that drives a complex motility and the epithelial lining. The epithelium is arranged in crypts that contain a variety of different cell types whose roles help effect absorption, protection and self-maintenance of the large intestinal epithelium. Digesta remains within the large intestine for much longer than other gastrointestinal compartments and so the composition of the luminal contents may have a greater potential to positively or negatively impact on gastrointestinal and systemic health. The current review aims to consider recent evidence that dietary fibres may impact on the physiological processes of the large intestine, with particular reference to the interplay of fibres with the resident microbiota.

Item Type: Article
Uncontrolled Keywords: Colonic crypt, Colorectal cancer, Dietary fibre, Intestinal microbiome, Laxation
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
D600 Food and Beverage studies
F100 Chemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Elena Carlaw
Date Deposited: 31 Oct 2019 12:35
Last Modified: 31 Oct 2019 12:35

Actions (login required)

View Item View Item


Downloads per month over past year

View more statistics