The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study

Kimble, Rachel, Murray, Lucy, Keane, Karen M., Haggerty, Karen, Howatson, Glyn and Lodge, John (2021) The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study. Journal of Nutritional Science, 10. e73. ISSN 2048-6790

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Montmorency tart cherries (MC) have been found to modulate indices of vascular function with interventions of varying duration. The objective of this preliminary study was to identify the chronic effects of MC supplementation on vascular function and the potential for urinary metabolomics to provide mechanistic evidence. We performed a placebo-controlled, double-blind, randomised study on 23 healthy individuals (18M, 7F) that consumed 30 ml MC or a placebo twice daily for 28 days. Whole body measures of vascular function and spot urine collections were taken at baseline and after supplementation. There were no significant changes to vascular function including blood pressure and arterial stiffness. Urinary metabolite profiling highlighted significant changes (P < 0⋅001) with putative discriminatory metabolites related to tryptophan and histidine metabolism. Overall, MC supplementation for 28 days does not improve indices of vascular function but changes to the urinary metabolome could be suggestive of potential mechanisms.

Item Type: Article
Additional Information: Funding information: We would like to thank the Cherry Marketing Institute for funding this research through a joint funded studentship (RK) with Northumbria University and also to the participants in this study. This work was made possible by a grant award to GH by the Michigan Cherry Committee.
Uncontrolled Keywords: Anthocyanin: Arterial stiffness: Blood pressure: Cherry: Metabolomics
Subjects: B400 Nutrition
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Elena Carlaw
Date Deposited: 25 Aug 2021 08:58
Last Modified: 28 Sep 2021 08:45

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