Tapered microfiber MZI Biosensor for highly sensitive detection of Staphylococcus aureus

Li, Hou-Chang, Leng, Yuan-Kui, Liao, Yun-Cheng, Liu, Bin, Luo, Wei, Liu, Juan, Shi, Jiu-Lin, Yuan, Jinhui, Xu, Heng-Yi, Xiong, Yong-Hua, He, Xing-Dao and Wu, Qiang (2022) Tapered microfiber MZI Biosensor for highly sensitive detection of Staphylococcus aureus. IEEE Sensors Journal, 22 (6). pp. 5531-5539. ISSN 1530-437X

Tapered_microfiber_MZI_Biosensor_for_highly_sensitive_detection_of_Staphylococcus_aureus.pdf - Accepted Version

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Official URL: https://doi.org/10.1109/JSEN.2022.3149004


A new double-taper microfiber Mach-Zehnder interferometer (MZI) biosensor is applied for Staphylococcus aureus (S. aureus) detection. The microfiber MZI structure is fabricated by creating two tapers along a traditional single mode fiber (SMF) firstly and tapering the SMF sandwiched between two tapers into very small diameter (in the order of micrometers). The measured refractive index (RI) sensitivity of the microfiber MZI is up to 2731.1 nm/RIU in the RI range of 1.34 when the taper waist diameter was 10.2 μm, which is in good agreement with numerical simulation results by using the beam propagation method (BPM). The microfiber MZI functionalized with pig immunoglobulin (pig IgG) could be used to specifically binding to S. aureus. In experiment, the maximum wavelength shift of 1.408 nm was achieved when the microfiber biosensors were immersed into S. aureus with concentration of 7×101 CFU/mL. The limit of detection (LoD) of the microfiber biosensor for S. aureus is calculated as low as 11 CFU/mL. The proposed microfiber MZI biosensor has advantages of simple structure configuration, high sensitivity, good repeatability and specificity, wide detection range and fast detection response time (<30 minutes) and thus was demonstrated a good application prospect in food safety inspection, biochemical sensing, diseases and medical diagnostics.

Item Type: Article
Additional Information: Funding information: This work was supported in part by the National Natural Science Foundations of China under Grant 11864025, Grant 62065013, and Grant 61865013; in part by the Key Research and Development Projects of Ministry of Science and Technology of China under Grant 2018YFE0115700; and in part by the Key Project of Natural Science Foundation of Jiangxi under Grant 20212BAB202024 and Grant 20192ACB20031.
Uncontrolled Keywords: biosensor, Biosensors, Mach-Zehnder interferometer (MZI), Optical fiber couplers, Optical fiber sensor, Optical fiber sensors, Optical interferometry, Sensitivity, Sensors, Staphylococcus aureus (S. aureus), Temperature sensors
Subjects: H100 General Engineering
H600 Electronic and Electrical Engineering
H800 Chemical, Process and Energy Engineering
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: Rachel Branson
Date Deposited: 02 Mar 2022 14:47
Last Modified: 08 Apr 2022 13:45
URI: http://nrl.northumbria.ac.uk/id/eprint/48596

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