Hobbs, Ditte, George, Trevor and Lovegrove, Julie (2014) Differential effect of beetroot bread on postprandial DBP according to Glu298Asp polymorphism in the eNOS gene: a pilot study. Journal of Human Hypertension, 28. pp. 726-730. ISSN 0950-9240
Full text not available from this repository. (Request a copy)Abstract
Our objective was to investigate whether the presence of Glu298Asp polymorphism in the endothelial NO synthase (eNOS) gene differentially affects the postprandial blood pressure response to dietary nitrate-rich beetroot bread. A randomised, single-blind, controlled, crossover acute pilot study was performed in 14 healthy men (mean age: 34±9 years) who were retrospectively genotyped for Glu298Asp polymorphism (7GG; T carriers 7). Volunteers were randomised to receive 200 g beetroot-enriched bread (1.1 mmol nitrate) or control bread (no beetroot; 0.01 mmol nitrate) on two separate occasions 10 days apart. Baseline and incremental area under the curve of blood pressure and NOx (nitrate/nitrite) were measured for a 6-h postprandial period. A treatment × genotype interaction was observed for diastolic blood pressure (P<0.02), which was significantly lower in T carriers (P<0.01) after consumption of beetroot bread compared with control bread. No significant differences were observed in the GG group. The beneficial diastolic blood pressure reduction was observed only in the T carriers of the Glu298Asp polymorphism in the eNOS gene after consumption of nitrate-rich beetroot bread. These data require confirmation in a larger population group.
| Item Type: | Article |
|---|---|
| Subjects: | B400 Nutrition D600 Food and Beverage studies |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Paul Burns |
| Date Deposited: | 07 Nov 2014 14:01 |
| Last Modified: | 12 Oct 2019 18:29 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/18003 |
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