Folate and epigenetics: why we should not forget bacterial biosynthesis

Kok, Dieuwertje, Steegenga, Wilma and McKay, Jill (2018) Folate and epigenetics: why we should not forget bacterial biosynthesis. Epigenomics, 10 (9). pp. 1147-1150. ISSN 1750-1911

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Folate, together with other B-vitamins, plays a crucial role in epigenetic regulation. Folate-mediated one-carbon metabolism refers to a complex network of interconnected metabolic pathways, which ultimately result in a supply of methyl groups for DNA, RNA or protein methylation. These epigenetic marks, particularly DNA methylation, have been proposed as plausible mechanisms underlying associations between folate and various disease outcomes, such as neural tube defects (NTDs), asthma, cardiometabolic disorders and cancer. However, evidence for the impact of folate on most of these disease outcomes, except for NTDs, is hampered by inconsistencies, with studies investigating the relationship between folate, DNA methylation and disease being subject to further complexities (i.e. identification of specific genomic loci affected, directions of differential methylation, and timing of epigenetic changes throughout the life course). Folate is closely related to other key role players in one-carbon metabolism (i.e. vitamin B12, homocysteine, methionine and choline) and therefore compensatory changes in interrelated metabolic pathways may account for inconsistent reports. Moreover, estimated folate intake does not necessarily correspond to circulating levels (correlations ranging from r=0.05–0.54), pointing towards methodological issues or other genetic, physiological or environmental factors determining folate levels. One particular aspect that remains unexplored is the contribution of bacterial folate biosynthesis to folate status and DNA methylation patterns.

Item Type: Article
Uncontrolled Keywords: folate; biosynthesis; one-carbon metabolism; intestinal bacteria; microbiota; DNA methylation; epigenetics
Subjects: B400 Nutrition
C400 Genetics
C500 Microbiology
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Paul Burns
Date Deposited: 03 Sep 2018 14:05
Last Modified: 10 Oct 2019 15:02

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