Kimble, Rachel, Keane, Karen M., Lodge, John, Cheung, William, Haskell-Ramsay, Crystal and Howatson, Glyn (2022) Polyphenol-rich tart cherries (Prunus Cerasus, cv Montmorency) improve sustained attention, feelings of alertness and mental fatigue and influence the plasma metabolome in middle-aged adults: a randomised, placebo-controlled trial. British Journal of Nutrition, 128 (12). pp. 2409-2420. ISSN 0007-1145
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polyphenol-rich-tart-cherries-prunus-cerasus-cv-montmorency-improve-sustained-attention-feelings-of-alertness-and-mental-fatigue-and-influence-the-plasma-metabolome-in-middle-aged-adults-a-randomised-.pdf - Published Version Available under License Creative Commons Attribution 4.0. Download (1MB) | Preview |
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polyphenol-rich-tart-cherries-prunus-cerasus-cv-montmorency-improve-sustained-attention-feelings-of-alertness-and-mental-fatigue-and-influence-the-plasma-metabolome-in-middle-aged-adults-a-randomised-.pdf - Published Version Available under License Creative Commons Attribution 4.0. Download (1MB) | Preview |
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Abstract
There is accumulating evidence for the protective effects of polyphenols on risk factors associated with cognitive decline and mood disorders. Tart Montmorency cherries (MC) are a particularly rich source of anthocyanins and other polyphenols that have been shown to elicit antioxidant, anti-inflammatory and vasomodulatory actions. This study aimed to determine the influence of chronic MC supplementation on cognitive function, mood, sleep, health and cerebral blood flow. In a 3-month double-blinded, placebo-controlled parallel study, middle-aged adults (mean ± SD: 48 ± 6 years) were randomly assigned to either 30 ml twice daily of MC (n = 25) or the same amount of an isocaloric placebo (n = 25). Cognitive function and mood were assessed before and after supplementation using a computerised cognitive task battery and visual analogue scales. Cerebral blood flow was also monitored by near-infrared spectroscopy during the task battery, questionnaires were administered to determine subjective sleep and health status and plasma metabolomics was analysed before and after supplementation. After 3 months, the MC resulted in higher accuracy in digit vigilance (mean difference: 3.3, 95CI: 0.2, 6.4) with lower number of false alarms (mean difference: -1.2, 95CI: -2.0, -0.4) compared to the placebo. There was also a treatment effect for higher alertness (mean difference: 5.9, 95CI: 1.3, 10.5) and lower mental fatigue ratings (mean difference -9.5, 95CI: -16.5, -2.5) with MC. Plasma metabolomics revealed an increase in a number of amino acids in response to MC intake, but not placebo. These data suggest an anti-fatiguing effect of MC supplementation as well as the ability to improve sustained attention during times of high cognitive demand, this might be related to changes in amino acid metabolism.
| Item Type: | Article |
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| Additional Information: | Funding information: This study was supported by Northumbria University and the Cherry Research Committee, a not-for-profit organisation, for a Collaborative Doctoral Research Studentship Scheme. The external funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. |
| Uncontrolled Keywords: | sustained attention, anthocyanins, cerebral blood flow, sleep, mental fatigue, Bond-Lader, metabolomics |
| Subjects: | B400 Nutrition C800 Psychology |
| Department: | Faculties > Health and Life Sciences > Applied Sciences Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation |
| Depositing User: | John Coen |
| Date Deposited: | 01 Feb 2022 09:28 |
| Last Modified: | 01 Dec 2022 16:00 |
| URI: | https://nrl.northumbria.ac.uk/id/eprint/48309 |
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